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Henry Blooms Cold Sore Relief 60c Blue silky liquid highlighter makeup forLysine deficiency has been associated with asthma, poor energy levels and low levels of thyroid hormones. Lysine appears to work with the amino acid arginine to build muscle however excessive dietary arginine leads to the depletion of Lysine. People such as athletes, vegans and those with a diet high in refined sugars may be particularly susceptible to lysine deficiency.